Mrs. C is the one character you shouldn't mess with. She's stored in the objects file under Program Files instead of having her own package file. You should write protect your files as described in my tutorial. The vamps have their own packages, and you can easily reduce the number to one by performing the NL step of "No Ugly Townies."
In Uni subhoods, the mascots, cheerleaders, and coaches are special characters. If you marry any of them, you need to do a BHAV transplant from a normal Sim or they'll suddenly change into their University outfits and perform their most annoying behaviors. Yes, they do this. I've seen it myself.
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